竞彩堂5分快3

竞彩堂5分快3固定學術報告:Finding Novel exRNA Biomarkers for the Liquid Biopsy of Cancer

作者: 2019-12-18 來源:
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報告人:鲁志教授 清华大学生命科学院

題目:Finding Novel exRNA Biomarkers for the Liquid Biopsy of Cancer

時間:2019年12月18日下午2:00

地點:生科大樓報告廳

主持人:王澤峰研究員,計算生物學重點實驗室

報告人簡介:鲁志博士,清华大学生命科学学院研究员,博士生导师,“生物信息学”教育部重点实验室副主任,国家“优秀青年”基金和“霍英东”青年基金获得者。2003年获中国科学技术大学生命学院学士学位,2008年获美国罗切斯特大学的生物物理学博士学位,2008-2010年在耶鲁大学从事生物信息学的博士後研究, 2011年加入清华大学建立生物信息学实验室。鲁志博士的实验室主要从事跟非编码RNA有关的生物信息学研究,包括(1)RNA調控和(2)精准醫療兩個重點方向。發表在國際重要期刊文章50余篇(Science, Cell Research, Genome Biology, Nature Communications, NAR等),總引用超過10000次。其中以通訊作者身份發表的20余篇(影響因子超過10的11篇)。曾獲清華大學“學術新人獎”,入選教育部“新世紀人才計劃”,入選清華大學“221基礎研究青年人才”計劃。

Abstract:Recent genomic studies suggest that potential novel long noncoding RNAs (lncRNAs) are specifically expressed and far outnumber annotated ncRNA sequences. To identify and characterize novel lncRNAs in sequencing data from new samples, we have developed a bioinformatics software package (http://software.ncrnalab.org) that includes 3 modules: RNAfinder, RNAstructurome and RNAtarget. We have applied them to many biological (i.e., plant) and medical (i.e., cancer) applications. For instance, based on RNAfinder, we have identified ~8K novel lncRNAs in HCC (liver cancer) samples. Many of them were further validated as metastasis associated lncRNA biomarkers.

Currently, the main research focus of our lab is to identify and study novel extra-cellular RNA (exRNA) biomarkers in bio-fluids associated with tumorigenesis and cancer development, using machine learning (AI) approaches and high-throughput sequencing technologies. By analyzing dynamic expression and variants, we hope to find novel exRNA species related to tumorigenesis and/or cancer progression from cell-free plasma/serum, micro-vesicles, exosomes, and RNPs. The identified exRNA biomarkers are applied to the most lethal cancer in China. Finally, we will deliver an accurate, reproducible and robust method for cancer early diagnosis and/or prognosis.

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